IUBMB Enzyme Nomenclature


Accepted name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase

Reaction: (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate

Other name(s): 2-hydroxy-5-methylmuconate semialdehyde hydrolase; todF (gene name)

Systematic name: 2-hydroxy-6-oxohepta-2,4-dienoate acetylhydrolase

Comments: A bacterial enzyme that participates in the degradation of toluene and 2-nitrotoluene.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Kukor, J.J. and Olsen, R.H. Genetic organization and regulation of a meta cleavage pathway for catechols produced from catabolism of toluene, benzene, phenol, and cresols by Pseudomonas pickettii PKO1. J. Bacteriol. 173 (1991) 4587-4594. [PMID: 1856161]

2. Menn, F.M., Zylstra, G.J. and Gibson, D.T. Location and sequence of the todF gene encoding 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase in Pseudomonas putida F1. Gene 104 (1991) 91-94. [PMID: 1916282]

3. Haigler, B.E., Wallace, W.H. and Spain, J.C. Biodegradation of 2-nitrotoluene by Pseudomonas sp. strain JS42. Appl. Environ. Microbiol. 60 (1994) 3466-3469. [PMID: 7944378]

[EC created 2019]

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