IUBMB Enzyme Nomenclature

EC 3.7.1.3

Accepted name: kynureninase

Reaction: L-kynurenine + H2O = anthranilate + L-alanine

For diagram of reaction click here.

Systematic name: L-kynurenine hydrolase

Comments: A pyridoxal-phosphate protein. Also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)-alanines.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9024-78-6

References:

1. Jakoby, W.B. and Bonner, D.M. Kynureninase from Neurospora: purification and properties. J. Biol. Chem. 205 (1953) 699-707. [PMID: 13129248]

2. Jakoby, W.B. and Bonner, D.M. Kynureninase from Neurospora: interactions of enzyme with substrates, coenzyme and amines. J. Biol. Chem. 205 (1953) 709-715. [PMID: 13129249]

3. Knox, W.E. The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency. Biochem. J. 53 (1953) 379-385. [PMID: 13032082]

4. Wiss, O. and Weber, F. Die Reindarstellung der Kynureninase. Hoppe-Seyler's Z. Physiol. Chem. 304 (1956) 232-240.

[EC 3.7.1.3 created 1965]


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