IUBMB Enzyme Nomenclature


Accepted name: phloretin hydrolase

Reaction: phloretin + H2O = phloretate + phloroglucinol

For diagram of reaction click here.

Glossary: phloretin = 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
phloretate = 3-(4-hydroxyphenyl)propanoate
phloroglucinol = benzene-1,3,5-triol

Other name(s): ErPhy; lactase-phlorerin hydrolase; C-acylphenol hydrolase; 2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase (incorrect)

Systematic name: phloretin acylhydrolase (phloroglucinol forming)

Comments: Also hydrolyses other C-acylated phenols related to phloretin. Isolated from the fungus Aspergillus niger and the bacteria Pantoea agglomerans and Eubacterium ramulus.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37289-38-6


1. Chatterjee, A.K. and Gibbins, L.N. Metabolism of phloridzin by Erwinia herbicola: nature of the degradation products, and the purification and properties of phloretin hydrolase. J. Bacteriol. 100 (1969) 594-600. [PMID: 5354935]

2. Minamikawa, T., Jayasankar, N.P., Bohm, B.A., Taylor, I.E. and Towers, G.H. An inducible hydrolase from Aspergillus niger, acting on carbon-carbon bonds, for phlorrhizin and other C-acylated phenols. Biochem. J. 116 (1970) 889-897. [PMID: 5441377]

3. Schoefer, L., Braune, A. and Blaut, M. Cloning and expression of a phloretin hydrolase gene from Eubacterium ramulus and characterization of the recombinant enzyme. Appl. Environ. Microbiol. 70 (2004) 6131-6137. [PMID: 15466559]

[EC created 1972, modified 2018]

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