IUBMB Enzyme Nomenclature


Accepted name: pyruvate decarboxylase

Reaction: a 2-oxo carboxylate = an aldehyde + CO2

Glossary: thiamine diphosphate

Other name(s): α-carboxylase (ambiguous); pyruvic decarboxylase; α-ketoacid carboxylase; 2-oxo-acid carboxy-lyase

Systematic name: 2-oxo-acid carboxy-lyase (aldehyde-forming)

Comments: A thiamine-diphosphate protein. Also catalyses acyloin formation.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9001-04-1


1. Singer, T.P. and Pensky, J. Isolation and properties of the α-carboxylase of wheat germ. J. Biol. Chem. 196 (1952) 375-388.

[EC created 1961]

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