IUBMB Enzyme Nomenclature


Accepted name: L-tryptophan decarboxylase

Reaction: L-typtophan = tryptamine + CO2

For diagram of reaction click here

Other name(s): psiD (gene name); TDC (gene name)

Systematic name: L-tryptophan carboxy-lyase

Comments: The enzyme has been characterized from bacteria, plants, and fungi. Unlike EC, aromatic-L-amino-acid decarboxylase, this enzyme is specific for L-typtophan.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Noe, W., Mollenschott, C. and Berlin, J. Tryptophan decarboxylase from Catharanthus roseus cell suspension cultures: purification, molecular and kinetic data of the homogenous protein. Plant Mol. Biol. 3 (1984) 281-288. [PMID: 24310513]

2. Buki, K.G., Vinh, D.Q. and Horvath, I. Partial purification and some properties of tryptophan decarboxylase from a Bacillus strain. Acta Microbiol Hung 32 (1985) 65-73. [PMID: 4036551]

3. Nakazawa, H., Kumagai, H. and Yamada, H. Constitutive aromatic L-amino acid decarboxylase from Micrococcus percitreus. Biochem. Biophys. Res. Commun. 61 (1974) 75-82. [PMID: 4441405]

4. Lopez-Meyer, M. and Nessler, C.L. Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminata which are differentially expressed during development and stress. Plant J. 11 (1997) 1167-1175. [PMID: 9225462]

5. Fricke, J., Blei, F. and Hoffmeister, D. Enzymatic synthesis of psilocybin. Angew. Chem. Int. Ed. Engl. 56 (2017) 12352-12355. [PMID: 28763571]

[EC created 2017]

Return to EC 4.1.1 home page
Return to EC 4.3 home page
Return to EC 4 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page