IUBMB Enzyme Nomenclature


Accepted name: indoleacetate decarboxylase

Reaction: (1H-indol-3-yl)acetate = skatole + CO2

For diagram of reaction click here.

Glossary: (1H-indol-3-yl)acetate = indoleacetate
skatole = 3-methyl-1H-indole

Other name(s): IAD

Systematic name: (1H-indol-3-yl)acetate carboxy-lyase (skatole-forming)

Comments: This glycyl radical enzyme has been isolate from a number of bacterial species. Skatole contributes to the characteristic smell of animal faeces.

Links to other databases: BRENDA, EXPASY, ExplorEnz, KEGG, MetaCyc, CAS registry number:


1. Liu, D., Wei, Y., Liu, X., Zhou, Y., Jiang, L., Yin, J., Wang, F., Hu, Y., Nanjaraj Urs, A.N., Liu, Y., Ang, E.L., Zhao, S., Zhao, H. and Zhang, Y. Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole. Nat. Commun. 9 (2018) 4224. [PMID: 30310076]

[EC created 2019]

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