IUBMB Enzyme Nomenclature


Accepted name: 3-oxoisoapionate decarboxylase

Reaction: 3-oxoisoapionate = L-erythrulose + CO2

Glossary: 3-oxoisoapionate = 2,4-dihydroxy-2-(hydroxymethyl)-3-oxobutanoate

Other name(s): oiaC (gene name)

Systematic name: 3-oxoisoapionate carboxy-lyase

Comments: The enzyme, characterized from several bacterial species, is involved in the degradation of D-apionate. Stereospecificity of 3-oxoisoapionate has not been determined.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Carter, M.S., Zhang, X., Huang, H., Bouvier, J.T., Francisco, B.S., Vetting, M.W., Al-Obaidi, N., Bonanno, J.B., Ghosh, A., Zallot, R.G., Andersen, H.M., Almo, S.C. and Gerlt, J.A. Functional assignment of multiple catabolic pathways for D-apiose. Nat. Chem. Biol. 14 (2018) 696-705. [PMID: 29867142]

[EC created 2020]

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