IUBMB Enzyme Nomenclature


Accepted name: phenyl-phosphate phosphatase/carboxylase

Reaction: 4-hydroxybenzoate + phosphate = phenyl phosphate + CO2 + H2O

Other name(s): phenyl phosphate carboxylase

Systematic name: 4-hydroxybenzoate carboxy-lyase (phenyl phosphate-forming)

Comments: The enzyme, characterized from the bacterium Thauera aromatica, participates in an anaerobic phenol degradation pathway. It catalyses the para dephosphorylation and carboxylation of phenylphosphate to 4-hydroxybenzoate. The enzyme from Thauera aromatica consists of four different subunits and requires K+ and a divalent metal cation (Mg2+ or Mn2+) for activity. It is strongly inhibited by oxygen.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Schuhle, K. and Fuchs, G. Phenylphosphate carboxylase: a new C-C lyase involved in anaerobic phenol metabolism in Thauera aromatica. J. Bacteriol. 186 (2004) 4556-4567. [PMID: 15231788]

[EC created 2022]

Return to EC 4.1.1 home page
Return to EC 4.3 home page
Return to EC 4 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page