Reaction: (1) 1'-carboxy-chondrochloren A + FAD = chondrochloren A + CO2 + FADH2
(2) 1'-carboxy-chondrochloren B + FAD = chondrochloren B + CO2 + FADH2
Glossary: chondrochloren A = (2R,3R,4R,5E,8S,9S,10R)-N-[(Z)-2-(3-chloro-4-hydroxyphenyl)ethenyl]-3,9-dihydroxy-2,4-dimethoxy-6,8,10-trimethyl-7-oxotetradec-5-enamide
chondrochloren B = (2R,3R,4R,5E,8S,9S,10R)-N-[(Z)-2-(3-chloro-4-hydroxyphenyl)ethenyl]-2-ethoxy-3,9-dihydroxy-4-methoxy-6,8,10-trimethyl-7-oxotetradec-5-enamide
Other name(s): cndG (gene name)
Systematic name: 1'-carboxy-chondrochloren carboxy-lyase
Comments: The enzyme, characterized from the bacterium Chondromyces crocatus, catalyses the final reactions in the biosynthesis of the antibiotics chondrochloren A andchondrochloren B.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Rachid, S., Revermann, O., Dauth, C., Kazmaier, U. and Muller, R. Characterization of a novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of chondrochloren from an acylated tyrosine. J. Biol. Chem. 285 (2010) 12482-12489. [PMID: 20080978]