Reaction: 4-hydroxy-3-methoxy- 5-all-trans-polyprenylbenzoate = 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2
Other name(s): COQ4
Systematic name: 4-hydroxy-3-methoxy-5-all-trans-polyprenylbenzoate carboxy-lyase
Comments: Requires Zn2+. The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone. The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Nicoll, C.R., Alvigini, L., Gottinger, A., Cecchini, D., Mannucci, B., Corana, F., Mascotti, M.L. and Mattevi, A. In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis. Nat. Catal. 7 (2024) 148-160. [PMID: 38425362]