IUBMB Enzyme Nomenclature


Accepted name: phosphoenolpyruvate carboxykinase (GTP)

Reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2

Other name(s): phosphoenolpyruvate carboxylase (ambiguous); phosphopyruvate carboxylase (ambiguous); phosphopyruvate (guanosine triphosphate) carboxykinase; phosphoenolpyruvic carboxykinase (GTP); phosphopyruvate carboxylase (GTP); phosphoenolpyruvic carboxylase (GTP); phosphoenolpyruvic carboxykinase (ambiguous); phosphoenolpyruvate carboxykinase (ambiguous); PEP carboxylase (ambiguous); GTP:oxaloacetate carboxy-lyase (transphosphorylating)

Systematic name: GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)

Comments: ITP can act as phosphate donor.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9013-08-5


1. Change, H.-C. and Lane, M.D. The enzymatic carboxylation of phosphoenolpyruvate. II. Purification and properties of liver mitochondrial phosphoenolpyruvate carboxykinase. J. Biol. Chem. 241 (1966) 2413-2420. [PMID: 5911620]

2. Kurahashi, K., Pennington, R.J. and Utter, M.J. Nucleotide specificity of oxalacetic carboxylase. J. Biol. Chem. 226 (1957) 1059-1075.

[EC created 1961]

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