Reaction: uroporphyrinogen III = coproporphyrinogen III + 4 CO2
For diagram of reaction click here.
Other name(s): uroporphyrinogen III decarboxylase; porphyrinogen carboxy-lyase; porphyrinogen decarboxylase; uroporphyrinogen-III carboxy-lyase
Systematic name: uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)
Comments: Acts on a number of porphyrinogens.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9024-70-8
References:
1. Mauzerall, D. and Granick, S. Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase. J. Biol. Chem. 232 (1958) 1141-1162.
2. Tomio, J.M., Garcia, R.C., San Martin de Viale, L.C. and Grinstein, M. Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes. Purification and properties. Biochim. Biophys. Acta 198 (1970) 353-363. [PMID: 4984554]