IUBMB Enzyme Nomenclature


Accepted name: uroporphyrinogen decarboxylase

Reaction: uroporphyrinogen III = coproporphyrinogen III + 4 CO2

For diagram of reaction click here.

Other name(s): uroporphyrinogen III decarboxylase; porphyrinogen carboxy-lyase; porphyrinogen decarboxylase; uroporphyrinogen-III carboxy-lyase

Systematic name: uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)

Comments: Acts on a number of porphyrinogens.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9024-70-8


1. Mauzerall, D. and Granick, S. Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase. J. Biol. Chem. 232 (1958) 1141-1162.

2. Tomio, J.M., Garcia, R.C., San Martin de Viale, L.C. and Grinstein, M. Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes. Purification and properties. Biochim. Biophys. Acta 198 (1970) 353-363. [PMID: 4984554]

[EC created 1965]

Return to EC 4.1.1 home page
Return to EC 4.3 home page
Return to EC 4 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page