IUBMB Enzyme Nomenclature



Accepted name: acetoacetate decarboxylase

Reaction: acetoacetate + H+ = acetone + CO2

For diagram click here.

Other name(s): acetoacetic acid decarboxylase; acetoacetate carboxy-lyase

Systematic name: acetoacetate carboxy-lyase (acetone-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9025-03-0


1. Davies, R. Studies of the acetone-butanol fermentation. 4. Acetoacetic acid decarboxylase of Cl. acetobutylicum (BY). Biochem. J. 37 (1943) 230-238.

2. Zerner, B., Coutts, S.M., Lederer, F., Waters, H.H. and Westheimer, F.H. Acetoacetate decarboxylase. Preparation of the enzyme. Biochemistry 5 (1966) 813-816. [PMID: 5911291]

3. Ho, M.C., Menetret, J.F., Tsuruta, H. and Allen, K.N. The origin of the electrostatic perturbation in acetoacetate decarboxylase. Nature 459 (2009) 393-397. [PMID: 19458715]

[EC created 1961]

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