IUBMB Enzyme Nomenclature


Accepted name: 5-guanidino-2-oxopentanoate decarboxylase

Reaction: 5-guanidino-2-oxopentanoate = 4-guanidinobutanal + CO2

Glossary: thiamine diphosphate

Other name(s): α-ketoarginine decarboxylase; 2-oxo-5-guanidinopentanoate carboxy-lyase

Systematic name: 5-guanidino-2-oxopentanoate carboxy-lyase (4-guanidinobutanal-forming)

Comments: enzyme activity is dependent on the presence of thiamine diphosphate and a divalent cation.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 56831-67-5


1. Vanderbilt, A.S., Gaby, N.S., Rodwell, V.W. Intermediates and enzymes between α-ketoarginine and γ-guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida. J. Biol. Chem. 250 (1975) 5322-5329. [PMID: 237915]

[EC created 1999]

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