IUBMB Enzyme Nomenclature


Accepted name: sulfopyruvate decarboxylase

Reaction: 3-sulfopyruvate = 2-sulfoacetaldehyde + CO2

For diagram of reaction click here

Glossary: thiamine diphosphate = 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-diphosphoethyl)-4-methyl-1,3-thiazolium
2-sulfoacetaldehyde = 2-oxoethanesulfonate

Other name(s): 3-sulfopyruvate carboxy-lyase

Systematic name: sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)

Comments: Requires thiamine diphosphate. Does not decarboxylate pyruvate or phosphonopyruvate. The enzyme appears to be oxygen-sensitive.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 303155-97-7


1. Graupner, M., Xu, H. and White, R.H. Identification of the gene encoding sulfopyruvate decarboxylase, an enzyme involved in biosynthesis of coenzyme M. J. Bacteriol. 182 (2000) 4862-4867. [PMID: 10940029]

[EC created 2002]

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