Reaction: (S)-4-hydroxymandelonitrile = cyanide + 4-hydroxybenzaldehyde
Other name(s): hydroxynitrile lyase; oxynitrilase; Sorghum hydroxynitrile lyase; (S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase
Systematic name: (S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)
Comments: does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10 mandelonitrile lyase and EC 4.1.2.39 hydroxynitrilase.
Comments: Does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10 (mandelonitrile lyase), EC 4.1.2.46 [aliphatic (R)-hydroxynitrile lyase] and EC 4.1.2.47 [(S)-hydroxynitrile ketone-lyase (cyanide forming)].
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9075-38-1
References:
1. Bové, C. and Conn, E.E. Metabolism of aromatic compounds in higher plants. II. Purification and properties of the oxynitrilase of Sorghum vulgare. J. Biol. Chem. 236 (1961) 207-210. [PMID: 16495254]
2. Seely, M.K., Criddle, R.S. and Conn, E.E. The metabolism of aromatic compounds in higher plants. 8. On the requirement of hydroxynitrile lyase for flavin. J. Biol. Chem. 241 (1966) 4457-4462. [PMID: 5922969]