IUBMB Enzyme Nomenclature


Accepted name: L-threo-3-deoxy-hexylosonate aldolase

Reaction: 2-dehydro-3-deoxy-L-galactonate = pyruvate + L-glyceraldehyde

Other name(s): GAAC; LGA1

Systematic name: 2-dehydro-3-deoxy-L-galactonate L-glyceraldehyde-lyase (pyruvate-forming)

Comments: The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Hilditch, S., Berghall, S., Kalkkinen, N., Penttila, M. and Richard, P. The missing link in the fungal D-galacturonate pathway: identification of the L-threo-3-deoxy-hexulosonate aldolase. J. Biol. Chem. 282 (2007) 26195-26201. [PMID: 17609199]

2. Martens-Uzunova, E.S. and Schaap, P.J. An evolutionary conserved D-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation. Fungal Genet. Biol. 45 (2008) 1449-1457. [PMID: 18768163]

[EC created 2013]

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