IUBMB Enzyme Nomenclature


Accepted name: dihydroneopterin phosphate aldolase

Reaction: 7,8-dihydroneopterin 3'-phosphate = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde phosphate

Other name(s): H2NMP aldolase

Systematic name: 7,8-dihydroneopterin 3'-phosphate glycolaldehyde phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]

Comments: The enzyme participates in methanopterin biosynthesis the archaeon Pyrococcus furiosus. The enzyme is specific for 7,8-dihydroneopterin 3'-phosphate. cf. EC, dihydroneopterin aldolase and EC, dihydroneopterin triphosphate aldolase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. de Crecy-Lagard, V., Phillips, G., Grochowski, L.L., El Yacoubi, B., Jenney, F., Adams, M.W., Murzin, A.G. and White, R.H. Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate. ACS Chem. Biol. 7 (2012) 1807-1816. [PMID: 22931285]

[EC created 2017]

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