IUBMB Enzyme Nomenclature


Accepted name: (4S)-4-hydroxy-2-oxoglutarate aldolase

Reaction: (4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate

Glossary: (4S)-4-hydroxy-2-oxoglutatrate = (S)-2-hydroxy-4-oxopentanedioate = L-4-hydroxy-2-oxoglutarate

Other name(s): 2-oxo-4-hydroxyglutarate aldolase (ambiguous); hydroxyketoglutaric aldolase (ambiguous); 4-hydroxy-2-ketoglutaric aldolase (ambiguous); 2-keto-4-hydroxyglutaric aldolase (ambiguous); 4-hydroxy-2-ketoglutarate aldolase (ambiguous); 2-keto-4-hydroxyglutarate aldolase (ambiguous); 2-oxo-4-hydroxyglutaric aldolase (ambiguous); hydroxyketoglutarate aldolase (ambiguous); 2-keto-4-hydroxybutyrate aldolase (ambiguous); 4-hydroxy-2-oxoglutarate glyoxylate-lyase (ambiguous); eda (gene name)

Systematic name: (4S)-4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

Comments: The enzyme from the bacterium Escherichia coli is specific for the (S)-enantiomer, is trifunctional, and also catalyses the reaction ofEC, 2-dehydro-3-deoxy-phosphogluconate aldolase, and the β-decarboxylation of oxaloacetate. cf. EC, 4-hydroxy-2-oxoglutarate aldolase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Nishihara, H. and Dekker, E.E. Purification, substrate specificity and binding, β-decarboxylase activity, and other properties of Escherichia coli 2-keto-4-hydroxyglutarate aldolase. J. Biol. Chem. 247 (1972) 5079-5087. [PMID: 4560498]

2. Patil, R.V. and Dekker, E.E. Cloning, nucleotide sequence, overexpression, and inactivation of the Escherichia coli 2-keto-4-hydroxyglutarate aldolase gene. J. Bacteriol. 174 (1992) 102-107. [PMID: 1339418]

[EC created 2013]

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