IUBMB Enzyme Nomenclature


Accepted name: benzylsuccinate synthase

Reaction: benzylsuccinate = toluene + fumarate

For diagram of reaction click here.

Other name(s): benzylsuccinate fumarate-lyase

Systematic name: benzylsuccinate fumarate-lyase (toluene-forming)

Comments: A glycyl radical enzyme that is inhibited by benzyl alcohol, benzaldehyde, phenylhydrazine and is inactivated by oxygen.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 209264-18-6


1. Beller, H.R. and Spormann, A.M. Analysis of the novel benzylsuccinate synthase reaction for anaerobic toluene activation based on structural studies of the product. J. Bacteriol. 180 (1998) 5454-5457. [PMID: 9765580]

2. Leuthner, B., Leutwein, C., Schultz, H., Hörth, P., Haehnel, W., Schiltz, E., Schägger, H. and Heider, J. Biochemical and genetic characterisation of benzylsuccinate synthase from Thauera aromatica: a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism. Mol. Microbiol. 28 (1998) 615-628. [PMID: 9632263]

[EC created 2000]

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