IUBMB Enzyme Nomenclature


Accepted name: 2-hydroxyisoflavanone dehydratase

Reaction: (1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O
(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O

For diagram of reaction click here or click here.

Glossary: daidzein = 4',7-dihydroxyisoflavone
genistein = 4',5,7-dihydroxyisoflavone

Other name(s): 2,7,4'-trihydroxyisoflavanone hydro-lyase; 2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming)

Systematic name: 2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)

Comments: Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 166800-10-8


1. Hakamatsuka, T., Mori, K., Ishida, S., Ebizuka, Y and Sankawa, U. Purification of 2-hydroxyisoflavanone dehydratase from the cell cultures of Pueraria lobata. Phytochemistry 49 (1998) 497-505.

[EC created 2004, modified 2013]

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