IUBMB Enzyme Nomenclature


Accepted name: phosphopyruvate hydratase

Reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O

For diagram of reaction click here.

Other name(s): enolase; 2-phosphoglycerate dehydratase; 14-3-2-protein; nervous-system specific enolase; phosphoenolpyruvate hydratase; 2-phosphoglycerate dehydratase; 2-phosphoglyceric dehydratase; 2-phosphoglycerate enolase; γ-enolase; 2-phospho-D-glycerate hydro-lyase

Systematic name: 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

Comments: Also acts on 3-phospho-D-erythronate.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, IUBMB-Nicholson Minimap (388 Kb PDF), Metacyc, PDB, CAS registry number: 9014-08-8


1. Holt, A. and Wold, F. The isolation and characterization of rabbit muscle enolase. J. Biol. Chem. 236 (1961) 3227-3231. [PMID: 13908561]

2. Malmström, B.G. Enolase, in Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 5, Academic Press, New York, 1961, pp. 471-494.

3. Westhead, E.W. and McLain, G. Purification of brewers' and bakers' yeast enolase yielding a single active component. J. Biol. Chem. 239 (1964) 2464-2468.

[EC created 1961]

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