IUBMB Enzyme Nomenclature


Accepted name: tetrahymanol synthase

Reaction: tetrahymanol = squalene + H2O

For diagram of reaction click here.

Glossary: tetrahymanol = gammaceran-3β-ol

Other name(s): squalene–tetrahymanol cyclase

Systematic name: squalene hydro-lyase (tetrahymanol forming)

Comments: The reaction occurs in the reverse direction.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Saar, J., Kader, J.C., Poralla, K. and Ourisson, G. Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila. Biochim. Biophys. Acta 1075 (1991) 93-101. [PMID: 1892870]

2. Giner, J.L., Rocchetti, S., Neunlist, S., Rohmer, M. and Arigoni, D. Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis. Chem. Commun. (Camb.) (2005) 3089-3091. [PMID: 15959594]

[EC created 2011]

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