IUBMB Enzyme Nomenclature


Accepted name: copal-8-ol diphosphate hydratase

Reaction: (13E)-8α-hydroxylabd-13-en-15-yl diphosphate = geranylgeranyl diphosphate + H2O

For diagram of reaction click here.

Glossary: (13E)-8α-hydroxylabd-13-en-15-yl diphosphate = 8-hydroxycopalyl diphosphate

Other name(s): CcCLS

Systematic name: geranylgeranyl-diphosphate hydro-lyase [(13E)-8α-hydroxylabd-13-en-15-yl diphosphate forming]

Comments: Requires Mg2+. The enzyme was characterized from the plant Cistus creticus subsp. creticus.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Falara, V., Pichersky, E. and Kanellis, A.K. A copal-8-ol diphosphate synthase from the angiosperm Cistus creticus subsp. creticus is a putative key enzyme for the formation of pharmacologically active, oxygen-containing labdane-type diterpenes. Plant Physiol. 154 (2010) 301-310. [PMID: 20595348]

[EC created 2012]

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