IUBMB Enzyme Nomenclature


Accepted name: (+)-caryolan-1-ol synthase

Reaction: (+)-β-caryophyllene + H2O = (+)-caryolan-1-ol

For diagram of reaction click here.

Glossary: (+)-caryolan-1-ol = (1S,2R,5S,8R)-4,4,8-trimethyltricyclo[,5]dodecan-1-ol

Other name(s): GcoA

Systematic name: (+)-β-caryophyllene hydrolase [cyclizing, (+)-caryolan-1-ol-forming]

Comments: A multifunctional enzyme which also forms (+)-β-caryophyllene from farnesyl diphosphate [EC, (+)-β-caryophyllene synthase].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Nakano, C., Horinouchi, S. and Ohnishi, Y. Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus. J. Biol. Chem. 286 (2011) 27980-27987. [PMID: 21693706]

[EC created 2011 as EC, transferred 2013 to EC]

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