IUBMB Enzyme Nomenclature


Accepted name: dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase

Reaction: dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = dTDP-4-dehydro-2,3,6-trideoxy-α-D-hexopyranose + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster

For diagram of reaction click here.

Other name(s): SpnQ; TDP-4-keto-2,6-dideoxy-D-glucose 3-dehydrase

Systematic name: dTDP-2,6-dideoxy-α-D-threo-hexopyranose hydro-lyase (dTDP-2,3,6-trideoxy-α-D-hexopyranose-forming)

Comments: A pyridoxal-phosphate protein. The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine. Requires ferredoxin/ferredoxin reductase or flavodoxin/flavodoxin reductase [1].

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Hong, L., Zhao, Z. and Liu, H.W. Characterization of SpnQ from the spinosyn biosynthetic pathway of Saccharopolyspora spinosa: mechanistic and evolutionary implications for C-3 deoxygenation in deoxysugar biosynthesis. J. Am. Chem. Soc. 128 (2006) 14262-14263. [PMID: 17076492]

2. Hong, L., Zhao, Z., Melancon, C.E., 3rd, Zhang, H. and Liu, H.W. In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa. J. Am. Chem. Soc. 130 (2008) 4954-4967. [PMID: 18345667]

[EC created 2016]

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