IUBMB Enzyme Nomenclature


Accepted name: trans-4-hydroxy-L-proline dehydratase

Reaction: trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H2O

Glossary: 1-pyrroline = 3,4-dihydro-2H-pyrrole

Systematic name: trans-4-hydroxy-L-proline hydro-lyase

Comments: The enzyme has been characterized from the bacterium Peptoclostridium difficile. The active form contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster.


1. Levin, B.J., Huang, Y.Y., Peck, S.C., Wei, Y., Martinez-Del Campo, A., Marks, J.A., Franzosa, E.A., Huttenhower, C. and Balskus, E.P. A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline. Science 355 (2017) . [PMID: 28183913]

[EC created 2017]

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