IUBMB Enzyme Nomenclature


Accepted name: difructose-anhydride-I synthase

Reaction: inulobiose = bis-D-fructose 2',1:2,1'-dianhydride + H2O

Glossary: α-D-fructofuranose-β-D-fructofuranose 2',1:2,1'-dianhydride = bis-D-fructose 2',1:2,1'-dianhydride = difructose anhydride I = DFA-I

Other name(s): DFAIase; inulobiose hydrolase; bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase

Systematic name: inulobiose hydro-lyase (α-D-fructofuranose-β-D-fructofuranose 2',1:2,1'-dianhydride-forming)

Comments: The enzyme, studied in the fungus Aspergillus fumigatus, may participate in an inulin degradation pathway in which it converts the product of EC, inulin fructotransferase (DFA-I-forming), to inulobiose, though in vitro activity was higher in the direction of DFA-I formation.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Matsuyama, T. and Tanaka, K. On the enzyme of Aspergillus fumigatus producing difructose anhydride I from inulobiose. Agric. Biol. Chem. 53 (1989) 831-832.

2. Matsuyama, T., Tanaka, K., Mashiko, M. and Kanamoto, M. Enzymic formation of di-D-fructose 1,2'; 2,1' dianhydride from inulobiose by Aspergillus fumigatus, J. Biochem. (Tokyo) 92 (1982) 1325-1328. [PMID: 6757245]

[EC created 1992 as EC, transferred to EC 2021]

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