IUBMB Enzyme Nomenclature


Accepted name: (E)-benzylidenesuccinyl-CoA hydratase

Reaction: (R,S)-2-(α-hydroxybenzyl)succinyl-CoA = (E)-benzylidenesuccinyl-CoA + H2O

Other name(s): bbsH (gene name)

Systematic name: (R,S)-2-(α-hydroxybenzyl)succinyl-CoA hydro-lyase

Comments: The enzyme, purified from the bacterium Thauera aromatica, is involved in an anaerobic toluene degradation pathway in which it catalyses the hydration of (E)-benzylidenesuccinyl-CoA.


1. von Horsten, S., Lippert, M.L., Geisselbrecht, Y., Schuhle, K., Schall, I., Essen, L.O. and Heider, J. Inactive pseudoenzyme subunits in heterotetrameric BbsCD, a novel short-chain alcohol dehydrogenase involved in anaerobic toluene degradation. FEBS J. (2021) . [PMID: 34601806]

[EC created 2022]

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