Reaction: (R)-5-phosphomevalonate = (2E)--3-methyl-5-phosphooxypent-2-enoate + H2O
Glossary:(2E)-3-methyl-5-phosphooxypent-2-enoate = trans-anhydromevalonate 5-phosphate
Systematic name: (R)-5-phosphomevalonate hydro-lyase
Comments: The enzyme catalyses a step in an archaeal prenyl diphosphate biosynthesis pathway. It belongs to the aconitase X family, and contains a [4Fe-4S] cluster.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Hayakawa, H., Motoyama, K., Sobue, F., Ito, T., Kawaide, H., Yoshimura, T. and Hemmi, H. Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate. Proc. Natl. Acad. Sci. USA 115 (2018) 10034–10039. [PMID: 30224495]
2. Yoshida, R., Yoshimura, T. and Hemmi, H. Reconstruction of the "archaeal" mevalonate pathway from the methanogenic archaeon Methanosarcina mazei in Escherichia coli cells. Appl. Environ. Microbiol. 86 (2020) e02889-19. [PMID: 31924615]
3. Komeyama, M., Kanno, K., Mino, H., Yasuno, Y., Shinada, T., Ito, T. and Hemmi, H. A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway. Front Microbiol. 14 (2023) 1150353. [PMID: 36992929]