Reaction: (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate = (9Z,11E)-12-[(1E)-hex-1-en-1-yloxy]dodeca-9,11-dienoate + H2O
Glossary: (9Z,11E)-12-[(1E)-hex-1-en-1-yloxy]dodeca-9,11-dienoic acid = etheroleic acid
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoic acid = 13(S)-HPOD
Other name(s): colneleic acid/etheroleic acid synthase; 13/9-DES; 9/13-DES; 13/9-divinyl ether synthase; (9Z,11E)-12-[(1E)-hex-1-en-1-yloxy]dodeca-9,11-dienoate synthase
Systematic name: (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate lyase
Comments: A heme-thiolate protein (P-450) occurring in several plants, including Allium sativum (garlic) and Selaginella moellendorffii (spikemoss). The enzyme also catalyses the reaction of EC 4.2.1.121, colneleate synthase, to a lesser extent.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Grechkin, A.N., Fazliev, F.N. and Mukhtarova, L.S. The lipoxygenase pathway in garlic (Allium sativum L.) bulbs: detection of the novel divinyl ether oxylipins. FEBS Lett. 371 (1995) 159-162. [PMID: 7672118]
2. Stumpe, M., Carsjens, J.G., Gobel, C. and Feussner, I. Divinyl ether synthesis in garlic bulbs. J. Exp. Bot. 59 (2008) 907-915. [PMID: 18326559]
3. Gorina, S.S., Toporkova, Y.Y., Mukhtarova, L.S., Smirnova, E.O., Chechetkin, I.R., Khairutdinov, B.I., Gogolev, Y.V. and Grechkin, A.N. Oxylipin biosynthesis in spikemoss Selaginella moellendorffii: Molecular cloning and identification of divinyl ether synthases CYP74M1 and CYP74M3. Biochim. Biophys Acta 1861 (2016) 301-309. [PMID: 26776054]