IUBMB Enzyme Nomenclature


Accepted name: 3-hydroxybutyryl-CoA dehydratase

Reaction: (3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O

For diagram of reaction click here.

Other name(s): D-3-hydroxybutyryl coenzyme A dehydratase; D-3-hydroxybutyryl-CoA dehydratase; enoyl coenzyme A hydrase (D); (3R)-3-hydroxybutanoyl-CoA hydro-lyase

Systematic name: (3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)

Comments: Also acts on crotonoyl thioesters of pantetheine and acyl-carrier protein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37290-82-7


1. Moskowitz, G.J. and Merrick, J.M. Metabolism of poly-β-hydroxybutyrate. II. Enzymatic synthesis of D-(–)-β hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum. Biochemistry 8 (1969) 2748-2755. [PMID: 5808333]

[EC created 1972]

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