IUBMB Enzyme Nomenclature


Accepted name: arogenate dehydratase

Reaction: L-arogenate = L-phenylalanine + H2O + CO2

For diagram click here.

Other name(s): carboxycyclohexadienyl dehydratase; L-arogenate hydro-lyase (decarboxylating)

Systematic name: L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)

Comments: Also acts on prephenate and D-prephenyllactate. cf. EC, prephenate dehydratase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 76600-70-9


1. Fischer, R. and Jensen, R. Arogenate dehydratase. Methods Enzymol. 142 (1987) 495-502. [PMID: 3600377]

2. Zamir, L.O., Tiberio, R., Devor, K.A., Sauriol, F., Ahmad, S. and Jensen, R.A. Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa. J. Biol. Chem. 263 (1988) 17284-17290. [PMID: 2972718]

3. Siehl, D.L. and Conn, E.E. Kinetic and regulatory properties of arogenate dehydratase in seedlings of Sorghum bicolor (L.) Moench. Arch. Biochem. Biophys. 260 (1988) 822-829. [PMID: 3124763]

[EC created 1992, modified 2005]

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