IUBMB Enzyme Nomenclature


Accepted name: heparin lyase

Reaction: Eliminative cleavage of polysaccharides containing (1→4)-linked D-glucuronate or L-iduronate residues and (1→4)-α-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-α-D-gluc-4-enuronosyl groups at their non-reducing ends

Other name(s): heparin eliminase; heparinase

Systematic name: heparin lyase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9025-39-2


1. Hovingh, P. and Linker, A. The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria. J. Biol. Chem. 245 (1970) 6170-6175. [PMID: 5484472]

[EC created 1972]

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