Reaction: geranyl diphosphate + H2O = (–)-endo-fenchol + diphosphate
For reaction pathway click here.
Other name(s): (–)-endo-fenchol cyclase; geranyl pyrophosphate:(–)-endo-fenchol cyclase
Systematic name: geranyl-diphosphate diphosphate-lyase [cyclizing, (–)-endo-fenchol-forming]
Comments: (3R)-Linalyl diphosphate is an intermediate in the reaction
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 117758-41-5
References:
1. Croteau, R., Miyazaki, J.H. and Wheeler, C.J. Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(–}-endo-fenchol cyclase from fennel (Foeniculum vulgare). Arch. Biochem. Biophys. 269 (1989) 507-516. [PMID: 2919880]
2. Croteau, R., Satterwhite, D.M., Wheeler, C.J. and Felton, N.M. Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (–}-endo-fenchol. J. Biol. Chem. 263 (1988) 15449-15453. [PMID: 3170591]