IUBMB Enzyme Nomenclature


Accepted name: (–)-endo-fenchol synthase

Reaction: geranyl diphosphate + H2O = (–)-endo-fenchol + diphosphate

For reaction pathway click here.

Other name(s): (–)-endo-fenchol cyclase; geranyl pyrophosphate:(–)-endo-fenchol cyclase

Systematic name: geranyl-diphosphate diphosphate-lyase [cyclizing, (–)-endo-fenchol-forming]

Comments: (3R)-Linalyl diphosphate is an intermediate in the reaction

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 117758-41-5


1. Croteau, R., Miyazaki, J.H. and Wheeler, C.J. Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(–}-endo-fenchol cyclase from fennel (Foeniculum vulgare). Arch. Biochem. Biophys. 269 (1989) 507-516. [PMID: 2919880]

2. Croteau, R., Satterwhite, D.M., Wheeler, C.J. and Felton, N.M. Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (–}-endo-fenchol. J. Biol. Chem. 263 (1988) 15449-15453. [PMID: 3170591]

[EC created 1992 as EC, transferred 2000 to EC]

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