IUBMB Enzyme Nomenclature


Accepted name: bicyclogermacrene synthase

Reaction: (2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate

For diagram of reaction click here.

Other name(s): Ov-TPS4

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (bicyclogermacrene-forming)

Comments: The enzyme from oregano (Origanum vulgare) gives mainly bicyclogermacrene with Mn2+ as a cofactor. With Mg2+ a more complex mixture is produced.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Crocoll, C., Asbach, J., Novak, J., Gershenzon, J. and Degenhardt, J. Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis. Plant Mol. Biol. 73 (2010) 587-603. [PMID: 20419468]

[EC created 2012]

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