Reaction: (2E,6E)-farnesyl diphosphate = sesquithujene + diphosphate
For diagram of reaction click here and mechanism click here.
Other name(s): TPS5-Del1
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (sesquithujene-forming)
Comments: The enzyme from Zea mays, variety Delprim, gives mainly sesquithujene with (S)-β-bisabolene and (E)-β-farnesene plus traces of other sesquiterpenoids, cf. EC 126.96.36.199 [(S)-β-bisabolene synthase] and EC 188.8.131.52 (β-farnesene synthase). It requires Mg2+ or Mn2+. The exact product ratio is dependent on which metal ion is present.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Köllner, T.G., Schnee, C., Gershenzon, J. and Degenhardt, J. The variability of sesquiterpenes emitted from two Zea mays cultivars is controlled by allelic variation of two terpene synthase genes encoding stereoselective multiple product enzymes. Plant Cell 16 (2004) 1115-1131. [PMID: 15075399]