IUBMB Enzyme Nomenclature


Accepted name: α-humulene synthase

Reaction: (2E,6E)-farnesyl diphosphate = α-humulene + diphosphate

For diagram of reaction click here.

Other name(s): ZSS1

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (α-humulene-forming)

Comments: The enzyme from Zingiber zerumbet, shampoo ginger, also gives traces of β-caryophyllene.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Yu, F., Okamto, S., Nakasone, K., Adachi, K., Matsuda, S., Harada, H., Misawa, N. and Utsumi, R. Molecular cloning and functional characterization of α-humulene synthase, a possible key enzyme of zerumbone biosynthesis in shampoo ginger (Zingiber zerumbet Smith). Planta 227 (2008) 1291-1299. [PMID: 18273640]

[EC created 2012]

Return to EC 4.2.3 home page
Return to EC 4.2 home page
Return to EC 4 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page