IUBMB Enzyme Nomenclature


Accepted name: sabinene-hydrate synthase

Reaction: geranyl diphosphate + H2O = sabinene hydrate + diphosphate

For reaction pathway click here.

Other name(s): sabinene hydrate cyclase

Systematic name: geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)

Comments: Both cis- and trans- isomers of sabinene hydrate are formed. (3R)-Linalyl diphosphate is an intermediate in the reaction

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 117164-95-1


1. Hallahan, T.W. and Croteau, R. Monoterpene biosynthesis: demonstration of a geranyl pyrophosphate:sabinene hydrate cyclase in soluble enzyme preparations from sweet marjoram (Majorana hortensis). Arch. Biochem. Biophys. 264 (1988) 618-631. [PMID: 3401015]

2. Hallahan, T.W. and Croteau, R. Monoterpene biosynthesis: mechanism and stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (+)-cis- and (+)-trans-sabinene hydrate. Arch. Biochem. Biophys. 269 (1989) 313-326. [PMID: 2916845]

[EC created 1992 as EC, transferred 2000 to EC]

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