IUBMB Enzyme Nomenclature


Accepted name: γ-muurolene synthase

Reaction: (2E,6E)-farnesyl diphosphate = γ-muurolene + diphosphate

For diagram of reaction click here.

Glossary: γ-muurolene = (1S,4aS,8aR)-1-isopropyl-7-methyl-4-methylene-1,2,3,4,4a,5,6,8a-octahydronaphthalene

Other name(s): Cop3

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lase (cyclizing, γ-muurolene-forming)

Comments: The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and α-muurolene, see EC, germacrene-A synthase and EC, α-muurolene synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Agger, S., Lopez-Gallego, F. and Schmidt-Dannert, C. Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus. Mol. Microbiol. 72 (2009) 1181-1195. [PMID: 19400802]

2. Lopez-Gallego, F., Wawrzyn, G.T. and Schmidt-Dannert, C. Selectivity of fungal sesquiterpene synthases: role of the active site's H-1α loop in catalysis. Appl. Environ. Microbiol. 76 (2010) 7723-7733. [PMID: 20889795]

[EC created 2012]

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