IUBMB Enzyme Nomenclature


Accepted name: 5-phosphooxy-L-lysine phospho-lyase

Reaction: (5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH3 + phosphate

Other name(s): 5-phosphohydroxy-L-lysine ammoniophospholyase; AGXT2L2 (gene name); 5-phosphonooxy-L-lysine phospho-lyase; (5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)

Systematic name: (5R)-5-phosphooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)

Comments: A pyridoxal-phosphate protein. Has no activity with phosphoethanolamine (cf. EC, ethanolamine-phosphate phospho-lyase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Tsai, C.H. and Henderson, L.M. Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase. J. Biol. Chem. 249 (1974) 5784-5789. [PMID: 4412716]

2. Veiga-da-Cunha, M., Hadi, F., Balligand, T., Stroobant, V. and Van Schaftingen, E. Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. J. Biol. Chem. 287 (2012) 7246-7255. [PMID: 22241472]

[EC created 2012]

Return to EC 4.2.3 home page
Return to EC 4.2 home page
Return to EC 4 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page