IUBMB Enzyme Nomenclature


Accepted name: Δ6-protoilludene synthase

Reaction: (2E,6E)-farnesyl diphosphate = Δ6-protoilludene + diphosphate

For diagram of reaction click here.

Glossary: Δ6-protoilludene = (4aS,7aS,7bR)-3,6,6,7b-tetramethyl-2,4,4a,5,6,7,7a,7b-octahydro-1H-cyclobuta[1,2-e]indene

Other name(s): 6-protoilludene synthase

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, Δ6-protoilludene-forming)

Comments: Isolated from the fungus Armillaria gallica. Δ6-Protoilludene is the first step in the biosynthesis of the melleolides.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Engels, B., Heinig, U., Grothe, T., Stadler, M. and Jennewein, S. Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides. J. Biol. Chem. 286 (2011) 6871-6878. [PMID: 21148562]

[EC created 2012]

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