IUBMB Enzyme Nomenclature


Accepted name: α-isocomene synthase

Reaction: (2E,6E)-farnesyl diphosphate = (–)-α-isocomene + diphosphate

For diagram of reaction click here.

Glossary: (–)-α-isocomene = (1R,3aS,5aS,8aR)-1,3a,4,5a-tetramethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene

Other name(s): MrTPS2

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (–)-α-isocomene-forming)

Comments: Isolated from the roots of the plant Matricaria chamomilla var. recutita (chamomile). The enzyme also produced traces of five other sesquiterpenoids.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Irmisch, S., Krause, S.T., Kunert, G., Gershenzon, J., Degenhardt, J. and Kollner, T.G. The organ-specific expression of terpene synthase genes contributes to the terpene hydrocarbon composition of chamomile essential oils. BMC Plant Biol. 12 (2012) 84. [PMID: 22682202]

[EC created 2012]

Return to EC 4.2.3 home page
Return to EC 4.2 home page
Return to EC 4 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page