IUBMB Enzyme Nomenclature


Accepted name: (+)-epi-α-bisabolol synthase

Reaction: (2E,6E)-farnesyl diphosphate + H2O = (+)-epi-α-bisabolol + diphosphate

For diagram of reaction click here.

Glossary: (+)-epi-α-bisabolol = (2S)-6-methyl-2-[(1R)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-epi-α-bisabolol-forming)

Comments: Isolated from the plant Phyla dulcis (Aztec sweet herb). (+)-epi-α-Bisabolol is the precursor of the sweetener hernandulcin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Attia, M., Kim, S.U. and Ro, D.K. Molecular cloning and characterization of (+)-epi-α-bisabolol synthase, catalyzing the first step in the biosynthesis of the natural sweetener, hernandulcin, in Lippia dulcis. Arch. Biochem. Biophys. 527 (2012) 37-44. [PMID: 22867794]

[EC created 2012]

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