IUBMB Enzyme Nomenclature


Accepted name: cis-abienol synthase

Reaction: (13E)-8α-hydroxylabd-13-en-15-yl diphosphate = cis-abienol + diphosphate

For diagram of reaction click here.

Glossary: cis-abienol = (12Z)-labda-12,14-dien-8α-ol
(13E)-8α-hydroxylabd-13-en-15-yl diphosphate = 8-hydroxycopalyl diphosphate

Other name(s): Z-abienol synthase; CAS; ABS

Systematic name: (13E)-8α-hydroxylabd-13-en-15-yl-diphosphate-lyase (cis-abienol forming)

Comments: Isolated from the plants Abies balsamea (balsam fir) [1] and Nicotiana tabacum (tobacco) [2].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Zerbe, P., Chiang, A., Yuen, M., Hamberger, B., Hamberger, B., Draper, J.A., Britton, R. and Bohlmann, J. Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production. J. Biol. Chem. 287 (2012) 12121-12131. [PMID: 22337889]

2. Sallaud, C., Giacalone, C., Topfer, R., Goepfert, S., Bakaher, N., Rosti, S. and Tissier, A. Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes. Plant J. 72 (2012) 1-17. [PMID: 22672125]

[EC created 2012]

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