Reaction: (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = ophiobolin F + diphosphate
For diagram of reaction click here.
Systematic name: (2E,6E,10E,14E)-geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, ophiobolin-F-forming)
Comments: Isolated from the fungus Aspergillus clavatus. The product is a sesterterpenoid (C25 terpenoid).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Chiba, R., Minami, A., Gomi, K. and Oikawa, H. Identification of ophiobolin F synthase by a genome mining approach: a sesterterpene synthase from Aspergillus clavatus. Org. Lett. 15 (2013) 594-597. [PMID: 23324037]