IUBMB Enzyme Nomenclature


Accepted name: (–)-spiroviolene synthase

Reaction: geranylgeranyl diphosphate = (–)-spiroviolene + diphosphate

For diagram of reaction click here and mechanism click here.

Glossary: (–)-spiroviolene = (2R,3a'S,3b'R,5R,6a'R)-2,4',4',5,6a'-pentamethyl-2',3',3a',3b',4',5',6',6a'-octahydrospiro[cyclopentane-1,1'-cyclopenta[a]pentalene]

Systematic name: geranylgeranyl-diphosphate diphosphate-lyase [cyclizing, (–)-spiroviolene-forming]

Comments: The enzyme, which forms the diterpene (–)-spiroviolene, has been characterized from the bacterium Streptomyces violens.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Rabe, P., Rinkel, J., Dolja, E., Schmitz, T., Nubbemeyer, B., Luu, T.H. and Dickschat, J.S. Mechanistic investigations of two bacterial diterpene cyclases: spiroviolene synthase and tsukubadiene synthase. Angew. Chem. Int. Ed. Engl. 56 (2017) 2776-2779. [PMID: 28146322]

[EC created 2017]

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