IUBMB Enzyme Nomenclature


Accepted name: (4S)-limonene synthase

Reaction: geranyl diphosphate = (S)-limonene + diphosphate

For diagram click here.

limonene: a monoterpenoid
(S)-limonene = (–)-limonene

Other name(s): (–)-(4S)-limonene synthase; 4S-(–)-limonene synthase; geranyldiphosphate diphosphate lyase (limonene forming); geranyl-diphosphate diphosphate-lyase [cyclizing, (4S)-limonene-forming]; geranyl-diphosphate diphosphate-lyase [cyclizing; (–)-(4S)-limonene-forming]; geranyl-diphosphate diphosphate-lyase [cyclizing; (4S)-limonene-forming]

Systematic name: geranyl-diphosphate diphosphate-lyase [cyclizing; (S)-limonene-forming]

Comments: A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 110639-20-8


1. Bohlmann, J., Steele, C.L. and Croteau, R. Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (–)-(4S)-limonene synthase, and (–)-(1S,5S)-pinene synthase. J. Biol. Chem. 272 (1997) 21784-21792. [PMID: 9268308]

2. Collby, S.M., Alonso, W.R., Katahira, E.J., McGarvey, D.J. and Croteau, R. 4S-Limonene synthase from the oil glands of spearmint (Mentha spicata). cDNA isolation, characterization, and bacterial expression of the catalytically active monoterpene cyclase. J. Biol. Chem. 268 (1993) 23016-23024. [PMID: 8226816]

3. Yuba, A., Yazaki, K., Tabata, M., Honda, G. and Croteau, R. cDNA cloning, characterization, and functional expression of 4S-(–)-limonene synthase from Perilla frutescens. Arch. Biochem. Biophys. 332 (1996) 280-287. [PMID: 8806736]

[EC created 2000 as EC, transferred 2000 to EC, modified 2003]

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