IUBMB Enzyme Nomenclature


Accepted name: 4-epi-cubebol synthase

Reaction: (2E,6E)-farnesyl diphosphate + H2O = 4-epi-cubebol + diphosphate

For diagram of reaction click here

Glossary: 4-epi-cubebol = (3S,3aS,3bR,4S,7S,7aS)-4-(2-hydroxypropan-2-yl)-7-methyloctahydro-1H-cyclopenta[1,3]cyclopropa[1,2]benzen-3-ol

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, 4-epi-cubebol-forming)

Comments: The enzyme, found in the bacterium Streptosporangium roseum, is specific for (2E,6E)-farnesyl diphosphate.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Rabe, P., Schmitz, T. and Dickschat, J.S. Mechanistic investigations on six bacterial terpene cyclases. Beilstein J. Org. Chem. 12 (2016) 1839-1850. [PMID: 27829890]

[EC created 2017]

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