IUBMB Enzyme Nomenclature


Accepted name: nezukol synthase

Reaction: (+)-copalyl diphosphate + H2O = nezukol + diphosphate

For diagram of reaction click here

Glossary: (+)-copalyl diphosphate = (2E)-3-methyl-5-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]pent-2-en-1-yl trihydrogen diphosphate
nezukol = pimar-15-en-8-ol

Other name(s): TPS2

Systematic name: (+)-copalyl-diphosphate diphosphate-lyase (cyclizing, nezukol-forming)

Comments: Isolated from the plant Isodon rubescens.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Pelot, K.A., Hagelthorn, D.M., Addison, J.B. and Zerbe, P. Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases. PLoS One 12 (2017) e0176507. [PMID: 28445526]

[EC created 2017]

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